First-principles and direct design approaches for the control of pharmaceutical crystallization
09 Jun 2023 | Contributor(s):: Fujiwara, Mitsuko, Nagy, Zoltan K. Chew, Jie W., Braatz, Richard D. ;
Crystallization is the main separation and purification process for the manufacturing of drug substances. Not only does crystallization affect the efficiency of downstream operations such as filtering, drying, and formulating, the efficacy of the drug can be dependent on the final crystal form....
Comparative performance of concentration and temperature controlled batch crystallizations
09 Jun 2023 | Contributor(s):: Nagy, Zoltan K., Chew, Jia W. Fujiwara, Mitsuko, Braatz, Richard D.
An increased interest has been directed towards the crystallization of pharmaceuticals and proteins in recent years, which have additional complications compared to the extensively studied inorganic batch and continuous crystallizations. Recent advances in process analytical technology have...