Continuous Flow Intensification for the Synthesis of High-Purity Warfarin
10 May 2024 | Contributor(s):: Silva-Brenes, Diana V., Reyes-Vargas, Stephanie K., Duconge, Jorge, Vlaar, Cornelis, Stelzer, Torsten, Monbaliu, Jean-Christophe M.
While racemic warfarin was initially commercialized as a rodenticide, it has become the most prescribed anticoagulant drug for prevention of blood clots and is part of the World Health Organization’s list of essential medicines. The synthesis of warfarin appears straightforward, consisting of a...
Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products
09 Jun 2023 | Contributor(s):: Porta, R, Benaglia, M, Puglisi, A
Recently, application of the flow technologies for the preparation of fine chemicals, such as natural products or Active Pharmaceutical Ingredients (APIs), has become very popular, especially in academia. Although pharma industry still relies on multipurpose batch or semibatch reactors, it is...