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Have you had challenges with CM adhesion/cohesion? Experts are discussing this topic in the Oral Solid Dosage Group,, broken out into the following key areas: conveying, feeding, transfer hoppers, and transition pipes. Learn from their experience by reading the full conversation here: https://cmkc.usp.org/groups/oralsoliddose/forum/default-section/discussions/111
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Tags: Organometallic Flow Chemistry Reaction

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Resources (1-2 of 2)

  1. Development of an Organometallic Flow Chemistry Reaction at Pilot Plant Scale for the Manufacture of Verubecestat

    out of 5 stars 

    Contributor(s):: Thaisrivongs, David A., Naber, John R., Rogus, Nicholas J., Spencer, Glenn

    We report the development of an organolithium addition to a chiral ketimine at pilot-plant scale using flow chemistry. Given the mixing sensitivity of this process, established previously at both lab and kilogram scale, we conducted critical experiments to understand the impact of flow rate,...

  2. Development of an Organometallic Flow Chemistry Reaction at PilotPlant Scale for the Manufacture of Verubecestat

    out of 5 stars 

    Contributor(s):: Thaisrivongs, David A., Naber, John R., Rogus, Nicholas J., Spencer, Glenn

    We report the development of an organolithium addition to a chiral ketimine at pilot-plant scale using flow chemistry. Given the mixing sensitivity of this process, established previously at both lab and kilogram scale, we conducted critical experiments to understand the impact of flow rate,...