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1. Process modelling, design and technoeconomic evaluation for continuous paracetamol crystallisation

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   Contributor(s):: Jolliffe, HG, Gerogiorgis, DI

   Continuous Pharmaceutical Manufacturing (CPM) has a strong potential to catalyse pharmaceutical innovation. This paper analyses Continuous Oscillatory Baffled Crystalliser (COBC) optimal design and performance for paracetamol crystallisation, via systematic modelling and nonlinear optimization...

2. Evaluation of crystallization kinetics of adipic acid in an oscillatory baffled crystallizer

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   Contributor(s):: Brown, C. J., Ni, X.

   For solution crystallization, nucleation can be characterized by the maximum sub-cooling (or metastable limit), which is known to vary with numerous process parameters. The relationship between the metastable limit and cooling rate is of particular interest, as it can be utilized to derive...