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1. Development and Scale-Up of Three Consecutive Continuous Reactions for Production of 6-Hydroxybuspirone

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   Contributor(s):: LaPorte, Thomas L., Hamedi, Mourad, DePue, Jeffrey S., Shen, Lifen, Watson, Daniel, Hsieh, Daniel

   This paper describes the development of a continuous, high yielding, and scalable enolization, oxidation, and quench process for the hydroxylation of the azapirone psychtropic agent buspirone to afford 6-hydroxybuspirone...

2. The Use of Molecular Oxygen in Pharmaceutical Manufacturing: Is Flow the Way to Go?

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   Contributor(s):: Hone, CA, Roberge, DM, Kappe, CO

   Molecular oxygen is arguably the greenest reagent available to the organic chemist. Most commonly, a diluted form of oxygen gas, consisting of less than 10% O-2 in N-2 ("synthetic air"), is used in pharmaceutical and fine chemical batch manufacturing to effectively address safety concerns when...