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1. Organophotocatalytic N-Demethylation of Oxycodone Using Molecular Oxygen

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   25 Jun 2024 | Contributor(s):: Chen, Yuesu, Glotz, GabrielCantillo, David, Kappe, C. Oliver

   N-Demethylation of oxycodone is one of the key steps in the synthesis of important opioid antagonists like naloxone or analgesics like nalbuphine. The reaction is typically carried out using stoichiometric amounts of toxic and corrosive reagents. Herein, we present a green and scalable...