Resources (1-2 of 2)

1. Continuous Flow Chemistry of Metal Mediated Carboxylation and α-Arylation Reactions

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   25 Jun 2024 | Contributor(s):: Venkatraman, Sripathy, Tweedie, Scott, McLaws, Mark, Lathbury, David

   Utility of continuous flow chemistry in a carboxylation reaction and palladium-mediated α-arylation reaction is described. A two-step carboxylation reaction of an aryl group involving an anion formation, followed by quench with gaseous carbon dioxide was developed on small scale using HDPE tubes...

2. Life cycle analysis of solvent reduction in pharmaceutical synthesis using continuous adsorption for palladium removal

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   09 Jun 2023 | Contributor(s):: Slater, CS, Savelski, MJ, Ruiz-Felix, MN

   The life cycle emissions associated with the reduction of wastes from an adsorption process to remove palladium complexes in drug manufacture have been evaluated. The study assessed a green improvement to a process step in an active pharmaceutical ingredient synthesis where palladium catalyst is...