Fast Claisen condensation reaction optimization in a continuous flow reactor
Contributor(s):: Michałek, Stanisław, Powała, Antoni, Gurba-Bryśkiewicz, Lidia, Piórkowska, Natalia, Olejkowska, Patrycja, Yamani, Abdellah, Ochal, Zbigniew, Dubiel, Krzysztof, Wieczorek, Maciej
In our previous study, we described the batch synthesis of CPL304110, an innovative pan-FGFR inhibitor. Herein, we transferred the Claisen condensation reaction, one of the synthesis steps to a continuous flow reactor. A simple solvent switch from ethanol to tetrahydrofuran shortened the original...