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1. Mechanistic modeling and parameter-adaptive nonlinear model predictive control of a microbioreactor

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   09 Jun 2023 | Contributor(s):: Hong, Moo Sun, Braatz, Richard D.

   Microbioreactors are a promising technology to accelerate biologic drug development. In aerobic cellular respiration, a potential limit to the productivity of such systems is the transport of oxygen from an external gas to the most oxygen-deficient cells, and the potential for excessive spatially...