Resources (1-4 of 4)

1. PharmaPy: An object-oriented tool for the development of hybrid pharmaceutical flowsheets

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   Contributor(s):: Casas-Orozco, Daniel, Laky, Daniel Wang, Vivian Abdi, Mesfin, Feng, X., Wood, E., Laird, Carl, Reklaitis, Gintaras V., Nagy, Zoltan K.

   Process design and optimization continue to provide computational challenges as the chemical engineering and process optimization communities seek to address more complex and larger scale applications. Software tools for digital design and flowsheet simulation are readily available for...

2. Optimization in seeded cooling crystallization: A parameter estimation and dynamic optimization study

   out of 5 stars 

   Contributor(s):: Nowee, S. Mostafa, Abbas, Ali, Romagnoli, Jose A.

   In this solution crystallization study, a population balance model that predicts the crystal size distribution (CSD) is used for targeting, by optimization, the product mean size and the coefficient of variation of the final CSD. The model is robust over a wide range of conditions and predicts...

3. Monitoring and digital design of the cooling crystallization of a high-aspect ratio anticancer drug using a two-dimensional population balance model

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   Contributor(s):: Szilágyi, Botond, Eren, Ayşe Quon, Justin L. Papageorgiou, Charles D., Nagy, Zoltán K.

   The development of a process model for the batch cooling crystallization of an anticancer drug from Takeda Pharmaceuticals is presented. The compound forms needle-like crystals that exhibit significant variation in shape (aspect ratio) during the crystallization. The parameters of a...

4. Model Based Estimation of 2D Crystallization Kinetics From Concentration and CLD Measurements

   out of 5 stars 

   Contributor(s):: Szilagyi, Botond, Borsos, Akos Simone, Elena Nagy, Zoltan K., Espuña, Antonio, Graells, Moisès, Puigjaner, Luis

   Due to the fact that crystal size and shape influence relevant macroscopic properties of solid particles, the understanding and control of these quantities have increasing importance in particulate science. Crystallization, the primary crystal formation and purification process, is usually...