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1. Investigation of the effect of impeller rotation rate, powder flow rate, and cohesion on powder flow behavior in a continuous blender using PEPT

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   09 Jun 2023 | Contributor(s):: Portillo, PM, Vanarase, AU, Ingram, A, Seville, JK, Ierapetritou, MG, Muzzio, FJ

   In this paper, we examine the movement of particles within a continuous powder mixer using PEPT (Positron Emission Particle Tracking). The benefit of the approach is that the particle movement along the vessel can be measured non-invasively. The effect of impeller rotation rate, powder flow rate,...

2. An Overview of Pharmaceutical Manufacturing for Solid Dosage Forms

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   09 Jun 2023 | Contributor(s):: Sacher, Stephan, Khinast, Johannes G.

   In this chapter, the main processing steps and manufacturing aspects of solid dosage forms are described and the relevant literature is reviewed. Starting with powder feeding, powder blending, granulation (dry and wet), and drying the most important unit operations to make compactable granules...

3. Analysis of powder phenomena inside a Fette 3090 feed frame using in-line NIR spectroscopy

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   09 Jun 2023 | Contributor(s):: Mateo-Ortiz Daniel, Colon, Yleana, Romañach, Rodolfo, Mendez, Rafael

   New analytical methods are needed to understand and optimize the processes by which tablets are produced. Fette 3090 tablet presses are commonly used in the pharmaceutical industry. A near-infrared (NIR) probe was installed into a Fette 3090 feed frame to understand and monitor the die filling...