Resources (1-4 of 4)

1. Real-Time Monitoring of Powder Mixing in a Convective Blender Using Non-Invasive Reflectance NIR Spectrometry

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   Contributor(s):: Bellamy, L. J., Littlejohn, D., Nordon, A.

   A convective blender based on a scaled down version of a high shear mixer-granulator was used to produce binary mixtures of microcrystalline cellulose (Avicel) and aspirin, citric acid, aspartame or povidone. Spectra of stationary Avicel or aspirin powder provided an indication of the information...

2. Industrial-Scale Continuous Vacuum Drying of Active Pharmaceutical Ingredient Paste: Determination of the Process Window

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   Contributor(s):: Aigner, I, Zettl, MSchroettner, H, van, der, Wel, P, Khinast, JG, Krumme, M

   Many efforts have been made in recent years to adopt and implement continuous processing into the pharmaceutical production chain, driven by the desire to optimize the process efficacy and cost as well as the product quality. In the current challenging times, the need for fast adaptable processes...

3. Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets

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   Contributor(s):: Fonteyne, Margot, Wickström, Henrika, Peeters, Elisabeth, Vercruysse, Jurgen, Ehlers, Henrik, Peters, Björn-Hendrik, Remon, Jean Paul, Vervaet, Chris, Ketolainen, Jarkko, Sandler, Niklas, Rantanen, Jukka., Naelapää, Kaisa

   Continuous manufacturing gains more and more interest within the pharmaceutical industry. The International Conference of Harmonisation (ICH) states in its Q8 'Pharmaceutical Development' guideline that the manufacturer of pharmaceuticals should have an enhanced knowledge of the product...

4. Engineering of acetaminophen particle attributes using a wet milling crystallisation platform

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   Contributor(s):: Ahmed, B, Brown, CJMcGlone, T, Bowering, DL, Sefcik, J, Florence, AJ

   Wet milling coupled with crystallisation has considerable potential to deliver enhanced control over particle attributes. The effect of process conditions and wet mill configuration on particle size, shape and surface energy has been investigated on acetaminophen using a seeded cooling...