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1. Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant

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   09 Jun 2023 | Contributor(s):: Berton, M, de, Souza, JMAbdiaj, I, McQuade, DT, Snead, DR

   The signature benefits of continuous flow are largely a result of a reactor's micro-sized features. However, as the technology gains industrial traction in the synthesis of active pharmaceutical ingredients (API), the reactors must be scaled to larger size to meet production demands. Often, the...

2. Reactor design and selection for effective continuous manufacturing of pharmaceuticals

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   09 Jun 2023 | Contributor(s):: Hu, Chuntian

   Pharmaceutical production remains one of the last industries that predominantly uses batch processes, which are inefficient and can cause drug shortages due to the long lead times or quality defects. Consequently, pharmaceutical companies are transitioning away from outdated batch lines, in large...

3. Flow Chemistry, Continuous Processing, and Continuous Manufacturing: A Pharmaceutical Perspective

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   09 Jun 2023 | Contributor(s):: May, SA

   Flow chemistry has become a vibrant area for Research Article over the past decade. This perspective is intended to capture insights on how these advances have and will continue to impact the development and commercialization of active pharmaceutical ingredients. A series of chemistry examples...