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1. Continuous reactive crystallization of an API in PFR-CSTR cascade with in-line PATs

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   Contributor(s):: Hu, CT, Shores, BTDerech, RA, Testa, CJ, Hermant, P, Wu, W, Shvedova, K, Ramnath, A, Al, Ismaili, LQ, Su, QL, Sayin, R, Born, SC, Takizawa, B, O'Connor, TF, Yang, XC, Ramanujam, S, Mascia, S

   The continuous reactive crystallization of an active pharmaceutical ingredient (API) in a plug flow reactor (PFR)-continuous stirred tank reactor (CSTR) cascade system with in-line PATs was developed and investigated. Residence time distribution (RTD) measurements of the PFR (stage 1), the CSTR...