Peer-reviewed journal (1-2 of 2)

1. Effect of material properties on the residence time distribution (RTD) of a tablet press feed frame

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   09 Jun 2023 | Contributor(s):: Furukawa, Ryoichi, Singh, Ravendra, Ierapetritou, Marianthi

   In continuous manufacturing (CM) of pharmaceutical tablets, the residence time distribution (RTD) of the tablet press feed frame plays an important role in ensuring the critical quality attributes (CQAs) of the final product. Knowledge of factors affecting the RTD of the feed frame is necessary...

2. A perspective on Quality-by-Control (QbC) in pharmaceutical continuous manufacturing

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   09 Jun 2023 | Contributor(s):: Su, Qinglin, Ganesh, Sudarshan Moreno, Mariana Bommireddy, Yasasvi, Gonzalez, Marcial, Reklaitis, Gintaras V., Nagy, Zoltan K.

   The Quality-by-Design (QbD) guidance issued by the US Food and Drug Administration (FDA) has catalyzed the modernization of pharmaceutical manufacturing practices including the adoption of continuous manufacturing. Active process control was highlighted recently as a means to improve the QbD...