-
Monitoring and digital design of the cooling crystallization of a high-aspect ratio anticancer drug using a two-dimensional population balance model
Contributor(s):: Szilágyi, Botond, Eren, Ayşe Quon, Justin L. Papageorgiou, Charles D., Nagy, Zoltán K.
The development of a process model for the batch cooling crystallization of an anticancer drug from Takeda Pharmaceuticals is presented. The compound forms needle-like crystals that exhibit significant variation in shape (aspect ratio) during the crystallization. The parameters of a...
-
Mathematical modeling and experimental validation of continuous slug-flow tubular crystallization with ultrasonication-induced nucleation and spatially varying temperature
Contributor(s):: Mozdzierz, Nicholas J., Lee, Yongkyu Hong, Moo Sun Benisch, Moritz H.P., Rasche, Michael L., Tropp, Uku Erik, Jiang, Mo, Myerson, Allan S., Braatz, Richard D.
Continuous slug-flow tubular crystallization has been explored by several Research Article groups in academia and industry as a way to produce crystals while having low capital equipment costs. In this crystallization type, slugs of slurry and gas consecutively travel through a tube, with a high...
-
Control of Drug-Excipient Particle Attributes with Droplet Microfluidic-based Extractive Solidification Enables Improved Powder Rheology
Contributor(s):: Ng, DZL, Nelson, AZWard, G, Lai, D, Doyle, PS, Khan, SA
Purpose Industrial implementation of continuous oral solid dosage form manufacturing has been impeded by the poor powder flow properties of many active pharmaceutical ingredients(APIs). Microfluidic droplet-based particle synthesis is an emerging particle engineering technique that enables the...
-
Continuous Pharmaceutical Crystallization from Solution
Contributor(s):: Price, CJ
Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing