Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts
10 May 2024 | Contributor(s):: Tsubogo, Tetsu, Oyamada, Hidekazu, Kobayashi, Shū
Chemical manufacturing is conducted using either batch systems or continuous-flow systems. Flow systems have several advantages over batch systems, particularly in terms of productivity, heat and mixing efficiency, safety, and reproducibility. However, for over half a century, pharmaceutical...