Continuous Crystallization of Paracetamol (Acetaminophen) Form II: Selective Access to a Metastable Solid Form
09 Jun 2023 | Contributor(s):: Agnew, LR, McGlone, TWheatcroft, HP, Robertson, A, Parsons, AR, Wilson, CC
The first continuous crystallization of a metastable polymorphic form of an active pharmaceutical ingredient is reported. Paracetamol form II, which displays enhanced solubility and compressibility in comparison to the stable form I, has been successfully crystallized in two continuous platforms:...