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Model predictive control in pharmaceutical continuous manufacturing: A review from a user's perspective
09 Jun 2023 | Contributor(s):: Jelsch, Morgane, Roggo, Yves, Kleinebudde, Peter, Krumme, Markus
Pharmaceutical continuous manufacturing is considered as an emerging technology by the regulatory agencies, which have defined a framework guided by an effective quality risk management. With the understanding of process dynamics and the appropriate control strategy, pharmaceutical continuous...
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Advanced Model Predictive Feedforward/Feedback Control of a Tablet Press
09 Jun 2023 | Contributor(s):: Haas, Nicholas Townsend, Ierapetritou, Marianthi, Singh, Ravendra
In continuous pharmaceutical manufacturing, real-time precise control of critical quality attributes (CQAs) is necessary for quality by design (QbD)-based manufacturing and real-time release (RTR) with minimum consumption of time, space, and resources. Pharmaceutical tablets can be produced...
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A Hybrid MPC-PID Control System Design for the Continuous Purification and Processing of Active Pharmaceutical Ingredients
09 Jun 2023 | Contributor(s):: Sen, M, Singh, R, Ramachandran, R
In this work, a hybrid MPC (model predictive control)-PID (proportional-integral-derivative) control system has been designed for the continuous purification and processing framework of active pharmaceutical ingredients (APIs). The specific unit operations associated with the purification and...