Peer-reviewed journal (1-3 of 3)

1. Model predictive control in pharmaceutical continuous manufacturing: A review from a user's perspective

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   09 Jun 2023 | Contributor(s):: Jelsch, Morgane, Roggo, Yves, Kleinebudde, Peter, Krumme, Markus

   Pharmaceutical continuous manufacturing is considered as an emerging technology by the regulatory agencies, which have defined a framework guided by an effective quality risk management. With the understanding of process dynamics and the appropriate control strategy, pharmaceutical continuous...

2. Advanced Model Predictive Feedforward/Feedback Control of a Tablet Press

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   09 Jun 2023 | Contributor(s):: Haas, Nicholas Townsend, Ierapetritou, Marianthi, Singh, Ravendra

   In continuous pharmaceutical manufacturing, real-time precise control of critical quality attributes (CQAs) is necessary for quality by design (QbD)-based manufacturing and real-time release (RTR) with minimum consumption of time, space, and resources. Pharmaceutical tablets can be produced...

3. A Hybrid MPC-PID Control System Design for the Continuous Purification and Processing of Active Pharmaceutical Ingredients

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   09 Jun 2023 | Contributor(s):: Sen, M, Singh, R, Ramachandran, R

   In this work, a hybrid MPC (model predictive control)-PID (proportional-integral-derivative) control system has been designed for the continuous purification and processing framework of active pharmaceutical ingredients (APIs). The specific unit operations associated with the purification and...