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1. Assessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride

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   Contributor(s):: Gerardy, R, Winter, MVizza, A, Monbaliu, JCM

   The batch-to-flow translation of inter-and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both inter-and intramolecular strategies imply the telescoping of multiple processing steps and the...