Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch to the Large-Scale Extrusion Processing
09 Jun 2023 | Contributor(s):: Stolar, T, Lukin, STireli, M, Sovic, I, Karadeniz, B, Kerekovic, I, Matijasic, G, Gretic, M, Katancic, Z, Dejanovic, I, di, Michiel, M, Halasz, I, Uzarevic, K
We demonstrate a controllable mechanochemical synthesis of cocrystal polymorphs of ascorbic acid (vitamin C) and nicotinamide (vitamin B3) on different scales and without using bulk solvents. Next to the previously described polymorph of the 1:1 cocrystal, which is one of the first cocrystals...