Melt extrusion with poorly soluble drugs - An integrated review
Contributor(s):: Repka, Michael A., Bandari, Suresh, Kallakunta, Venkata Raman, Vo, Anh Q., McFall, Haley, Pimparade, Manjeet B., Bhagurkar, Ajinkya M.
Over the last few decades, hot melt extrusion (HME) has emerged as a successful technology for a broad spectrum of applications in the pharmaceutical industry. As indicated by multiple publications and patents, HME is mainly used for the enhancement of solubility and bioavailability of poorly...
Development of immediate release 3D-printed dosage forms for a poorly water-soluble drug by fused deposition modeling: Study of morphology, solid state and dissolution
Contributor(s):: Fanous, M, Bitar, MGold, S, Sobczuk, A, Hirsch, S, Ogorka, J, Imanidis, G
3D-printing technologies such as Fused Deposition Modeling (FDM) bring a unique opportunity for personalized and flexible near-patient production of pharmaceuticals, potentially improving safety and efficacy for some medications. However, FDM-printed tablets often exhibit tendency for slow...