Micro-viscoelastic characterization of compressed oral solid dosage forms with ultrasonic wave dispersion analysis
Contributor(s):: Sultan, Tipu, Paul, Shubhajit, Rozin, Enamul Hasan, Tseng, Yin-Chao, Bazzocchi, Michael C. F., Cetinkaya, Cetin
Due to their constituent powders, the materials of advanced compressed oral solid dosage (OSD) forms are micro-composites and strongly visco-elastic at macro- and micro-length scales. The disintegration, drug release, and mechanical strength of OSD forms depend on its micro-texture (such as...
Early detection of capping risk in pharmaceutical compacts
Contributor(s):: Xu, Xiaochi, Vallabh, Chaitanya Krishna Prasad, Hoag, Stephen W., Dave, Vivek S., Cetinkaya, Cetin
Capping is a common mechanical defect in tablet manufacturing, exhibited during or after the compression process. Predicting tablet capping in terms of process variables (e.g. compaction pressure and speed) and formulation properties is essential in pharmaceutical industry. In current work, a...