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Improvement of a pharmaceutical powder mixing process in a tote blender via DEM simulations
Peer-reviewed journal | 04 Jun 2024 | Contributor(s):: Benedict Benque, Luca Orefice, Thomas Forgber, Matthias Habeler, Beate Schmid, Johan Remmelgas, Johannes Khinast
An industrial-scale pharmaceutical powder blending process was studied via discrete element method (DEM) simulations. A DEM model of two active pharmaceutical ingredient (API) components and a combined excipient component was calibrated by matching the simulated response in a dynamic angle of...
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Simulation-Based Design of an Efficient Control System for the Continuous Purification and Processing of Active Pharmaceutical Ingredients
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sen, M, Singh, R, Ramachandran, R
In this study, an efficient system-wide controlsystem has been designed for the integrated continuous purification and processing of the active pharmaceutical ingredient (API). The control strategy is based on the regulatory PID controller which is most widely used in the manufacturing industry...
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Process dynamics and control of API manufacturing and purification processes
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sen, Maitraye, Singh, Ravendra, Ramachandran, Rohit
The pharmaceutical industries have started transitioning toward continuous mode of manufacturing recently. Due to many advantages of the continuous manufacturing over the traditional alternatives, the industries are putting huge effort to efficiently adapt the continuous processing mode. However,...
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Multi-scale flowsheet simulation of an integrated continuous purification-downstream pharmaceutical manufacturing process
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sen, M, Chaudhury, ASingh, R, John, J, Ramachandran, R
Properties of active pharmaceutical ingredients influence the critical quality attributes (CQAs) of final solid dosage forms (e. g. tablets). In the last decade, continuous manufacturing has been shown to be a promising alternative to batch processing in the pharmaceutical industry. Therefore, a...
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Impact of excipients on batch and continuous powder blending
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Jaspers, M, de, Wit, MTWKulkarni, SS, Meir, B, Janssen, PHM, van, Haandel, MMW, Dickhoff, BHJ
Stimulated by Pharma 4.0, the pharmaceutical industry is changing from batch-wise to continuous manufacturing. Therefore, individual processing steps such as blending of the active pharmaceutical ingredient (API) with excipients have to be re-designed to continuous operations. In this study,...
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Flowsheet optimization of an integrated continuous purification-processing pharmaceutical manufacturing operation
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sen, Maitraye, Rogers, Amanda Singh, Ravendra Chaudhury, Anwesha John, Joyce Ierapetritou, Marianthi G, Ramachandran, Rohit
In this work, a continuous API purification process has been optimized using an integrated flowsheet model. The simulation is dynamic in nature and includes an API purification step (crystallization), followed by filtration, drying and mixing of the API with an excipient. For the first time, this...
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Diminished segregation in continuous powder mixing
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Oka, S, Sahay, A, Meng, W, Muzzio, F
Binary powder mixtures with variable segregation tendencies were mixed in a tumbling batch blender and in a continuous convective tubular blender. The degree of homogeneity of the final blend obtained from the continuous blender was found to be much higher than that from the batch V-blender, for...
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A Hybrid MPC-PID Control System Design for the Continuous Purification and Processing of Active Pharmaceutical Ingredients
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sen, M, Singh, R, Ramachandran, R
In this work, a hybrid MPC (model predictive control)-PID (proportional-integral-derivative) control system has been designed for the continuous purification and processing framework of active pharmaceutical ingredients (APIs). The specific unit operations associated with the purification and...