Real-time feedback control of twin-screw wet granulation based on image analysis
09 Jun 2023 | Contributor(s):: Madarasz, Lajos, Hoffer, Istvan, Szabo, Barnabas, Csontos, Istvan, Pataki, Hajnalka, Demuth, Balazs, Szabo, Bence, Csorba, Kristof, Nagy, Zsombor Kristof, Marosi, Gyorgy
The present paper reports the first dynamic image analysis-based feedback control of continuous twin-screw wet granulation process. Granulation of the blend of lactose and starch was selected as a model process. The size and size distribution of the obtained particles were successfully monitored...
In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending and tableting process
09 Jun 2023 | Contributor(s):: Nagy, Brigitta, Farkas, Attila, Gyurkes, Martin, Komaromy-Hiller, Szofia, Demuth, Balazs, Szabo, Bence, Nusser, David, Borbas, Eniko, Marosi, Gyorgy, Nagy, Zsombor Kristof
The integration of Process Analytical Technology (PAT) initiative into the continuous production of pharmaceuticals is indispensable for reliable production. The present paper reports the implementation of in-line Raman spectroscopy in a continuous blending and tableting process of a...