Inline Determination of Residence Time distributionin Hot-Melt-Extrusion
Contributor(s):: Wesholowski, Jens, Berghaus, Andreas, Thommes, Markus
In the framework of Quality-by-Design (QbD), the inline determination of process parameters or quality attributes of a product using sufficient process analytical technology (PAT) is a center piece for the establishment of continuous processes as a standard pharmaceutical technology. In this...
Continuous Manufacturing of High Quality Pharmaceutical Cocrystals Integrated with Process Analytical Tools for In-Line Process Control
Contributor(s):: Moradiya, Hiren G., Islam, Muhammad, Scoutaris, Nikolaos, Halsey, Sheelagh, Chowdhry, Babur Z., Douroumis, Dennis
A continuous manufacturing process for pharmaceutical indomethacin saccharine cocrystals was achieved by extrusion processing with high throughput. Down-stream milling and blending of the extrudates was followed by feeding the formulated cocrystals in a capsule-filling machine. By applying a...