Peer-reviewed journal (1-3 of 3)

1. Simplified end-to-end continuous manufacturing by feeding API suspensions in twin-screw wet granulation

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   09 Jun 2023 | Contributor(s):: Schmidt, A, de, Waard, HMoll, KP, Kleinebudde, P, Krumme, M

   This study focussed on investigating the coupling of continuous manufacturing of drug substance and continuous manufacture of drug product. An important step in such an integrated end-to-end continuous manufacturing was envisioned by dosing the API as suspension into a twin-screw wet granulation...

2. Control of three different continuous pharmaceutical manufacturing processes: Use of soft sensors

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   09 Jun 2023 | Contributor(s):: Rehrl, J, Karttunen, APNicolai, N, Hormann, T, Horn, M, Korhonen, O, Nopens, I, De, Beer, T, Khinast, JG

   One major advantage of continuous pharmaceutical manufacturing over traditional batch manufacturing is the possibility of enhanced in-process control, reducing out-of-specification and waste material by appropriate discharge strategies. The decision on material discharge can be based on the...

3. Continuous manufacturing – the Green Chemistry promise?

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   09 Jun 2023 | Contributor(s):: Klavs F. Jensen

   Continuous manufacturing and Green Chemistry, are two promising approaches to synthesis with underutilized potential that are gaining traction by the wider pharmaceutical community. We review Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green...