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Tags: Process optimization

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  1. Mike Tyler

    https://cmkc.usp.org/members/2524

  2. Use of a continuous twin screw granulation and drying system during formulation development and process optimization

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    09 Jun 2023 | Contributor(s):: Vercruysse, J., Peeters, E., Fonteyne, M., Cappuyns, P., Delaet, U., Van Assche, I., De Beer, T., Remon, J. P., Vervaet, C.

    Since small scale is key for successful introduction of continuous techniques in the pharmaceutical industry to allow its use during formulation development and process optimization, it is essential to determine whether the product quality is similar when small quantities of materials are...

  3. Impact of blend properties and process variables on the blending performance

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    09 Jun 2023 | Contributor(s):: Bekaert, B, Grymonpre, W, Novikova, A, Vervaet, C, Vanhoorne, V

    In this study, quantitative relationships were established between blend properties, process settings and blending responses via multivariate data-analysis. Four divergent binary blends were composed in three different ratios and processed at various throughputs and impeller speeds. Additionally,...

  4. Crystal shape and size control using a plug flow crystallization configuration

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    09 Jun 2023 | Contributor(s):: Sang-Il Kwon, Joseph, Nayhouse, Michael Orkoulas, Gerassimos

    This work focuses on modeling and control of a continuous plug flow crystallizer (PFC) used to produce tetragonal hen-egg-white (HEW) lysozyme crystals and proposes an optimization-based control scheme to produce crystals with desired size and shape distributions in the presence of disturbances....

  5. Application of a System Model for Continuous Manufacturing of an Active Pharmaceutical Ingredient in an Industrial Environment

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    09 Jun 2023 | Contributor(s):: Diab, S, Bano, GChristodoulou, C, Hodnett, N, Benedetti, A, Andersson, M, Zomer, S

    Purpose In pharmaceutical manufacturing, understanding and quantifying how process conditions impact product quality is pivotal to guaranteeing process profitability with sustained product yield. We describe an integrated system model for a commercial-scale continuous manufacturing process of a...