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  1. Reducing the mean size of API crystals by continuous manufacturing with product classification and recycle

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    09 Jun 2023 | Contributor(s):: Griffin, DW, Mellichamp, DA, Doherty, MF

    A continuous crystallization process is proposed that can produce active pharmaceutical ingredients with a small mean size and narrow distribution. The process flowsheet consists of a new product classifier configuration where the large crystals from the classifier are recycled to a dissolver...