Recent advances in integrated process analytical techniques, modeling, and control strategies to enable continuous biomanufacturing of monoclonal antibodies
Contributor(s):: Chopda, Viki, Gyorgypal, Aron Yang, Ou Singh, Ravendra Ramachandran, Rohit Zhang, Haoran Tsilomelekis, George Chundawat, Shishir PS, Ierapetritou, Marianthi G
Continuous bioprocessing is significantly changing the biological drugs (or biologics) manufacturing landscape by potentially improving product quality, process stability, and overall profitability, as was similarly seen during the adoption of advanced manufacturing processes for small molecule...
pH and Conductivity Control in an Integrated Biomanufacturing Plant
Contributor(s):: Lu, Amos E, Paulson, Joel A Braatz, Richard D, Fellow, Ieee
This paper designs pH and conductivity control systems for a biomanufacturing platform that specializes in the production of biologically derived medicines on demand. Dynamic models and control strategies are presented for a buffer mixing unit that must produce high quality buffers for use within...