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1. In Situ Characterization of Waters of Hydration in a Variable-Hydrate Active Pharmaceutical Ingredient Using Cl-35 Solid-State NMR and X-ray Diffraction

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   Contributor(s):: Hirsh, DA, Holmes, STChakravarty, P, Peach, AA, DiPasquale, AG, Nagapudi, K, Schurko, RW

   Variable-hydrate active pharmaceutical ingredients (APIs) are known to form thermodynamically and kinetically stabilized solid phases over a continuous range of nonstoichiometric hydration levels. Some of these forms can be problematic in the production of solid dosage forms (e.g., tablets and...