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  1. 7-Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir

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    | Contributor(s):: Ziegler, RE, Desai, BKJee, JA, Gupton, BF, Roper, TD, Jamison, TF

    Dolutegravir (DTG), an important active pharmaceutical ingredient (API) used in combination therapy for the treatment of HIV, has been synthesized in continuous flow. By adapting the reported GlaxoSmithKline process chemistry batch route for Cabotegravir, DTG was produced in 4.5h in sequential...