Real-Time Monitoring of Powder Mixing in a Convective Blender Using Non-Invasive Reflectance NIR Spectrometry
Contributor(s):: Bellamy, L. J., Littlejohn, D., Nordon, A.
A convective blender based on a scaled down version of a high shear mixer-granulator was used to produce binary mixtures of microcrystalline cellulose (Avicel) and aspirin, citric acid, aspartame or povidone. Spectra of stationary Avicel or aspirin powder provided an indication of the information...
Detailed Analysis of the Online Near-Infrared Spectra of Pharmaceutical Blend in a Rotary Tablet Press Feed Frame
Contributor(s):: Šašić, Slobodan, Blackwood, Daniel, Liu, Angela, Ward, Howard W, Clarke, Hugh
The present study is an in-depth analysis of the online near-infrared (NIR) spectra acquired with a spectrometer mounted on the rotary tablet press feed frame. A 3.5% active pharmaceutical ingredient (API) formulation is analyzed. An attempt is made to determine the API univariately via the 2nd...