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1. Batch vs. continuous direct compression – a comparison of material processability and final tablet quality

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   | Contributor(s):: S. Fathollahi, D. Vanderroost, T. Roelofs, B.H.J. Dickhoff, C. Vervaet, V. Vanhoorne, B. Bekaert, P.H.M. Janssen

   In this study, an in-depth comparison was made between batch and continuous direct compression using similar compression set-ups. The overall material processability and final tablet quality were compared and evaluated. Correlations between material properties, process parameters and final...

2. Systematic development of a high dosage formulation to enable direct compression of a poorly flowing API: A case study

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   | Contributor(s):: Schaller, BE, Moroney, KM, Castro-Dominguez, B, Cronin, P, Belen-Girona, J, Ruane, P, Croker, DM, Walker, GM

   In this work, the transfer of oral solid dosage forms, currently manufactured via wet granulation, to a continuous direct compression process was considered. Two main challenges were addressed: (1) a poorly flowing API (Canagliflozin) and (2) high drug loading (51 wt%). A scientific approach was...

3. Development of a continuous direct compression platform for low-dose drug products

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   | Contributor(s):: Van Snick, B, Holman, J, Vanhoorne, V, Kumar, A, De Beer, T, Remon, JP, Vervaet, C

   In this work a continuous direct compression process was developed for a low-dosed drug product. Each unit operation of the GEA CDC-50 system was thoroughly investigated. This paper aimed to tackle the macroscopic and microscopic blend uniformity challenges inherently associated with continuous...