Mass spectrometric directed system for the continuous-flow synthesis and purification of diphenhydramine
Contributor(s):: Loren, BP, Wleklinski, MKoswara, A, Yammine, K, Hu, YY, Nagy, ZK, Thompson, DH, Cooks, RG
A highly integrated approach to the development of a process for the continuous synthesis and purification of diphenhydramine is reported. Mass spectrometry (MS) is utilized throughout the system for on-line reaction monitoring, off-line yield quantitation, and as a reaction screening module that...