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Process Simulation and Control for Continuous Pharmaceutical Manufacturing of Solid Drug Products
09 Jun 2023 | Contributor(s):: Ierapetritou, Marianthi, Escotet-Espinoza, M Sebastian, Singh, Ravendra
This chapter focuses on the application and development of unit operation and process models of the major routes of continuous solid dose manufacturing. Process models developed in the chapter are very important tools for the design of control system. The chapter also focuses on the current...
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An Overview of Pharmaceutical Manufacturing for Solid Dosage Forms
09 Jun 2023 | Contributor(s):: Sacher, Stephan, Khinast, Johannes G.
In this chapter, the main processing steps and manufacturing aspects of solid dosage forms are described and the relevant literature is reviewed. Starting with powder feeding, powder blending, granulation (dry and wet), and drying the most important unit operations to make compactable granules...
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Advanced Control of Continuous Pharmaceutical Tablet Manufacturing Processes
09 Jun 2023 | Contributor(s):: Singh, Ravendra, Velazquez, Carlos Sahay, Abhishek Karry, Krizia M Muzzio, Fernando J Ierapetritou, Marianthi G, Ramachandran, Rohit
A novel manufacturing strategy based on continuous processing, integrated with online/inline monitoring tools, coupled with an advanced automatic feedback control system is highly desired for efficient Quality by Design (QbD)-based manufacturing of the next generation of pharmaceutical products...
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A Digital Twin for Process Optimisation in Pharmaceutical Manufacturing
09 Jun 2023 | Contributor(s):: Gerogiorgis, Dimitrios I., Castro-Rodriguez, Daniel
Organic synthesis is a critical step in producing any Active Pharmaceutical Ingredient (API): it encompasses a series of organic (mostly catalytic) reactions and separations, whose purpose is to arrive at a solution of a target molecule, which must then undergo crystallisation for purification,...