All Categories (1-3 of 3)

1. Multi-dimensional population balance modeling and experimental validation of continuous powder mixing processes

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   09 Jun 2023 | Contributor(s):: Sen, Maitraye, Singh, Ravendra Vanarase, Aditya John, Joyce, Ramachandran, Rohit

   It has been recognized that the application of quality by design (QbD) to continuous processing in the pharmaceutical industry leads to better process control, improved product quality and mitigates scale-up issues (Schaber et al., 2011), whereby a component of QbD involves the development...

2. Mathematical development and comparison of a hybrid PBM-DEM description of a continuous powder mixing process

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   09 Jun 2023 | Contributor(s):: Sen, Maitraye, Dubey, Atul Singh, Ravendra, Ramachandran, Rohit

   This paper describes the development of a multidimensional population balance model (PBM) which can account for the dynamics of a continuous powder mixing/blending process. The PBM can incorporate the important design and process conditions and determine their effects on the various critical...

3. Diminished segregation in continuous powder mixing

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   09 Jun 2023 | Contributor(s):: Oka, S, Sahay, A, Meng, W, Muzzio, F

   Binary powder mixtures with variable segregation tendencies were mixed in a tumbling batch blender and in a continuous convective tubular blender. The degree of homogeneity of the final blend obtained from the continuous blender was found to be much higher than that from the batch V-blender, for...