Peer-reviewed journal (1-3 of 3)

1. Development of a high-fidelity digital twin using the discrete element method for a continuous direct compression process. Part 2. Validation of calibration workflow

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   Peer-reviewed journal | 30 Oct 2024 | Contributor(s):: Peter Toson, Marko Matić, Theresa Hörmann-Kincses, Michela Beretta, Jakob Rehrl, Johannes Poms, Peter Boehling, Thomas O’Connor, Abdollah Koolivand, Geng Tian, Scott M. Krull, Johannes G. Khinast, Johan Remmelgas, Dalibor Jajcevic

   This paper is the second in a series of two that describes the application of discrete element method (DEM) and reduced order modeling to predict the effect of disturbances in the concentration of drug substance at the inlet of a continuous powder mixer on the concentration of the drug...

2. Residence Time Distribution (RTD)-Based Control System for Continuous Pharmaceutical Manufacturing Process

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Bhaskar, Aparajith, Singh, Ravendra

3. Residence time distribution modelling and in line monitoring of drug concentration in a tablet press feed frame containing dead zones

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Tanimura, Shinji, Singh, Ravendra Román-Ospino, Andrés D, Ierapetritou, Marianthi

   The presence of a ‘significant dead zone’ in any continuous manufacturing equipment may affect the product quality and need to be investigated systematically. Dead zone will affect the residence time distribution (RTD) of continuous manufacturing and thus the mixing and product quality. Tablet...