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Systematic investigation of the impact of screw elements in continuous wet granulation
Peer-reviewed journal | 10 Sep 2024 | Contributor(s):: Katharina Kiricenko, Peter Kleinebudde, Robin Meier
Twin-screw wet granulation (TSG) is a continuous manufacturing technique either for granules as final dosage form or as an intermediate before tableting or capsule filling. A comprehensive process understanding is required to implement TSG, considering various parameters influencing granule and...
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Validation of a continuous granulation process using a twin-screw extruder
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Van Melkebeke, B., Vervaet, C., Remon, J. P.
Using twin-screw granulation as particle size enlargement technique, the effect of modifying the screw configuration (number of mixing zones, configuration of kneading block) on granule quality, tablet properties and mixing efficiency was investigated. The amount of oversized agglomerates and...
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The effect of screw configuration and formulation variables on liquid requirements and granule quality in a continuous twin screw wet granulation process
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Vandevivere, L., Van Wijmeersch, E., Hausler, O., De Beer, T., Vervaet, C., Vanhoorne, V.
The effect of two screw configurations with varying stagger angle was evaluated on the liquid amount required to produce good quality granules for a highly (mannitol-based) and a poorly (DCP-based) soluble formulation containing different binders. It is generally known that the use of a higher...
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Impact of screw configuration on the particle size distribution of granules produced by twin screw granulation
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Vercruysse, J, Burggraeve, A., Fonteyne, M., Cappuyns, P., Delaet, U., Van Assche, I., De Beer, T., Remon, J. P., Vervaet, C.
Twin screw granulation (TSG) has been reported by different Research Article groups as an attractive technology for continuous wet granulation. However, in contrast to fluidized bed granulation, granules produced via this technique typically have a wide and multimodal particle size distribution...
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Continuous twin screw wet granulation: The combined effect of process parameters on residence time, particle size, and granule morphology
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Shirazian, Saeed, Zeglinski, Jacek, Darwish, Shaza, Kuhs, Manuel, Albadarin, Ahmad B., Croker, Denise M., Walker, Gavin M.
In this study, a set of 24 experiments was designed to understand the combined effect of different process parameters, i.e. material feed rate, liquid-to-solid (L/S) ratio, screw speed, and screw configuration on the residence time distribution, granule morphology, and particle size distribution...