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Process scheduling under uncertainty : Review and challenges
Contributor(s):: Li, Zukui, Ierapetritou, Marianthi
Uncertainty is a very important concern in production scheduling since it can cause infeasibilities and production disturbances. Thus scheduling under uncertainty has received a lot of attention in the open literature in recent years from chemical engineering and operations research communities....
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Quality Risk Assessment and Mitigation of Pharmaceutical Continuous Manufacturing Using Flowsheet Modeling Approach
Contributor(s):: Tian, Geng;, Koolivand, Abdollah, Arden, Nilou S., Lee, Sau, O'Connor, Thomas F.
Integrated flowsheet modeling is an engineering approach that can provide a framework for understanding the impact of process dynamics on drug quality and associated risks during production, thereby facilitating the development of robust continuous processes. In this investigation, flowsheet...
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Modeling a seeded continuous crystallizer for the production of active pharmaceutical ingredients
Contributor(s):: Besenhard, M. O., Hohl, R. Hodzic, A. Eder, R. J.P., Khinast, J. G.
The approximation of a well mixed reactor is prevalent when it comes to the modeling of a crystallization process. Since temperature, concentration, and mass content vary due to inhomogeneous mixing, this approximation is a very loose one. The continuously operated seeded tubular crystallizer...
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Dynamic flowsheet model development and digital design of continuous pharmaceutical manufacturing with dissolution modeling of the final product
Contributor(s):: Nagy, Brigitta, Szilágyi, Botond Domokos, András Vészi, Blanka, Tacsi, Kornélia, Rapi, Zsolt, Pataki, Hajnalka, Marosi, György, Nagy, Zoltán K., Nagy, Zsombor Kristóf
The integration of continuous unit operations imposes a challenge on the pharmaceutical companies aspiring to achieve plant-wide continuous manufacturing due to the additional complexity of the dynamic interactions, process control and quality assurance. To overcome this challenge, flowsheet...
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Dynamic flowsheet model development and sensitivity analysis of a continuous pharmaceutical tablet manufacturing process using the wet granulation route
Contributor(s):: Metta, Nirupaplava, Ghijs, Michael Schäfer, Elisabeth Kumar, Ashish Cappuyns, Philippe Van Assche, Ivo Singh, Ravendra Ramachandran, Rohit De Beer, Thomas, Ierapetritou, Marianthi
In view of growing interest and investment in continuous manufacturing, the development and utilization of mathematical model(s) of the manufacturing line is of prime importance. These models are essential for understanding the complex interplay between process-wide critical process parameters...
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Development and implementation of an advanced model predictive control system into continuous pharmaceutical tablet compaction process
Contributor(s):: Bhaskar, Aparajith, Barros, Fernando N, Singh, Ravendra
In the context of continuous pharmaceutical oral dosage manufacturing, a control system is essential to ensure that the critical quality attributes (CQAs) are maintained within the regulatory constraints by mitigating variations generated in upstream operations. Such a system is essential to the...