Peer-reviewed journal (1-2 of 2)

1. Development of a Continuous Schotten–Baumann Route to an Acyl Sulfonamide

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   24 Apr 2024 | Contributor(s):: White, Timothy D., Berglund, K. Derek, Groh, Jennifer McClary, Johnson, Martin D., Yates, Matthew H.

   The development and scale-up of a synthetic route to tasisulam sodium (5-bromo-thiophene-2-sulfonic acid 2,4-dichlorobenzoylamide sodium salt, hereafter referred to as tasisulam) utilizing continuous Schotten–Baumann reaction conditions is disclosed. A new synthetic route for the cytotoxic API...

2. Continuous Processing of Active Pharmaceutical Ingredients Suspensions via Dynamic Cross-Flow Filtration

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   09 Jun 2023 | Contributor(s):: Gursch, J, Hohl, RToschkoff, G, Dujmovic, D, Brozio, J, Krumme, M, Rasenack, N, Khinast, J

   Over the last years, continuous manufacturing has created significant interest in the pharmaceutical industry. Continuous filtration at low flow rates and high solid loadings poses, however, a significant challenge. A commercially available, continuously operating, dynamic cross-flow filtration...