All Categories (1-4 of 4)

1. A Comparative Investment Analysis of Batch Versus Continuous Pharmaceutical Manufacturing Technologies

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   Peer-reviewed journal | 04 Oct 2023 | Contributor(s):: Clifford V. Rossi

   Purpose This study examines the risks and economics associated with investing in continuous (CM) versus conventional batch manufacturing for production of oral solid dosage pharmaceutical (OSD) products in the USA and abroad. Methods A stochastic net present value (NPV) simulation of brand...

2. Population balance model-based multiobjective optimization of a multisegment multiaddition (MSMA) continuous plug-flow antisolvent crystallizer

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Ridder, Bradley J., Majumder, Aniruddha, Nagy, Zoltan K.

   Crystallization is a major separation process in the pharmaceutical industry. Most crystallizations are performed batchwise, but there is great incentive for converting them to continuous operations. This paper investigates the modeling, simulation, and optimization of a special antisolvent...

3. A multi-scale hybrid CFD-DEM-PBM description of a fluid-bed granulation process

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sen, Maitraye, Barrasso, Dana Singh, Ravendra, Ramachandran, Rohit

   In this study, a hybrid multi-scale model has been developed for a continuous fluid bed wet granulation process by dynamically coupling computational fluid dynamics (CFD) with a discrete element model (DEM) and population balance model (PBM). In this process, the granules are formed by spraying...

4. A flowsheet model for the development of a continuous process for pharmaceutical tablets: An industrial perspective

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Garcia-Munoz, Salvador, Butterbaugh, Adam Leavesley, Ian Manley, Leo Francis, Slade, David, Bermingham, Sean

   A dynamic model of a continuous direct compression process for pharmaceutical tablets is presented. The objective is to assess the impact of the variability from the feeder system on the concentration of drug in the powder in the feed frame of a tablet press. The model is based on principles of...