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1. Future Supply Chains Enabled by Continuous Processing - Opportunities and Challenges

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   09 Jun 2023 | Contributor(s):: Jagjit Singh Srai, Markus Krumme, Mauricio Futran, Clive Badman, Craig Johnston

   This paper examines the opportunities and challenges facing the pharmaceutical industry in moving to a primarily “continuous processing”-based supply chain. The current predominantly “large batch” and centralized manufacturing system designed for the “blockbuster” drug has driven a slow-paced,...

2. Continuous manufacturing via hot-melt extrusion and scale up: regulatory matters

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   09 Jun 2023 | Contributor(s):: Mohammed Maniruzzaman, Ali Nokhodchi

   Over recent decades, HME techniques have appeared as an innovative manufacturing platform for various pharmaceutical applications. HME has been successfully applied to develop multiple drug delivery systems for various applications (e.g., solubility enhancement, sustained release, taste masking,...