Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation: An experimental investigation
Contributor(s):: Kumar, Ashish, Alakarjula, Maija, Vanhoorne, Valerie, Toiviainen, Maunu, De Leersnyder, Fien, Vercruysse, Jurgen, Juuti, Mikko, Ketolainen, Jarkko, Vervaet, Chris, Remon, Jean Paul, Gernaey, Krist V., De Beer, Thomas, Nopens, Ingmar
Twin-screw granulation is a promising wet granulation technique for the continuous manufacturing of pharmaceutical solid dosage forms. A twin screw granulator displays a short residence time. Thus, the solid-liquid mixing must be achieved quickly by appropriate arrangement of transport and...