In Situ Characterization of Waters of Hydration in a Variable-Hydrate Active Pharmaceutical Ingredient Using Cl-35 Solid-State NMR and X-ray Diffraction
09 Jun 2023 | Contributor(s):: Hirsh, DA, Holmes, STChakravarty, P, Peach, AA, DiPasquale, AG, Nagapudi, K, Schurko, RW
Variable-hydrate active pharmaceutical ingredients (APIs) are known to form thermodynamically and kinetically stabilized solid phases over a continuous range of nonstoichiometric hydration levels. Some of these forms can be problematic in the production of solid dosage forms (e.g., tablets and...
Formation of organic molecular nanocrystals under soft confinement
09 Jun 2023 | Contributor(s):: Yang, XC, Ong, TCMichaelis, VK, Heng, S, Griffin, RG, Myerson, AS
Methods to produce nano-sized organic molecular crystals in thin films are of great interest in the pharmaceutical industry due to the potential benefit of increased solubility of poorly soluble drugs and the advantages of film-based dosage forms over traditional tablet/capsule-based dosage...