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1. overcoming poor solubility in active ingredient processing

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   What are the best strategies for overcoming poor solubility for materials related to the drug substance synthesis as part of solution processing?

   https://cmkc.usp.org/forum/defaultsection/general/20

2. Intermolecular hydrogen transfer and solubility tuning in multi-component molecular crystals of the API piroxicam

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   09 Jun 2023 | Contributor(s):: Thomas, LH, Klapwijk, ARWales, C, Wilson, CC

   A series of twelve multi-component molecular crystals of the active pharmaceutical ingredient (API) piroxicam (PX) have been synthesised and their structures analysed with respect to their supramolecular motifs and degree of intermolecular hydrogen transfer observed on formation of the various...

3. Continuous Crystallization of Aliskiren Hemifumarate

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   09 Jun 2023 | Contributor(s):: Quon, JL, Zhang, HAlvarez, A, Evans, J, Myerson, AS, Trout, BL

   Active ingredients in most pharmaceutical products are complex organic molecules that require crystallization as a purification and isolation step that results in a pure product at a high process yield. Knowledge of the operating conditions required to obtain crystals with the desired crystal...

4. Computer Aided Design of Solvent Blends for Hybrid Cooling and Antisolvent Crystallization of Active Pharmaceutical Ingredients

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   09 Jun 2023 | Contributor(s):: Watson, OL, Jonuzaj, SMcGinty, J, Sefcik, J, Galindo, A, Jackson, G, Adjiman, CS

   Choosing a solvent and an antisolvent for a new crystallization process is challenging due to the sheer number of possible solvent mixtures and the impact of solvent composition and crystallization temperature on process performance. To facilitate this choice, we present a general computer aided...