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Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses
Contributor(s):: De Meyer, Laurens, Lammens, Joris, Mortier, Severine Therese F. C., Vanbillemont, Brecht, Van Bockstal, Pieter Jan, Corver, Jos, Nopens, Ingmar, Vervaet, Chris, De Beer, Thomas
In the pharmaceutical industry, traditional freeze-drying of unit doses is a batch-wise process associated with many disadvantages. To overcome these disadvantages and to guarantee a uniform product quality and high process efficiency, a continuous freeze-drying process is developed and...
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Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process
Contributor(s):: Van Bockstal, Pieter-Jan, Mortier, Severine Therese F. C., De Meyer, Laurens, Corver, Jos, Vervaet, Chris, Nopens, Ingmar, De Beer, Thomas
Conventional pharmaceutical fieeze-drying is an inefficient and expensive batch-wise process, associated with several disadvantages leading to an uncontrolled end product variability. The proposed continuous alternative, based on spinning the vials during freezing and on optimal energy supply...
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Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses
Contributor(s):: De Meyer, L., Van Bockstal, P. -J., Corver, J., Vervaet, C., Remon, J. P., De Beer, T.
Spin-freezing as alternative freezing approach was evaluated as part of an innovative continuous pharmaceutical freeze-drying concept for unit doses. The aim of this paper was to compare the sublimation rate of spin-frozen vials versus traditionally frozen vials in a batch freeze-dryer, and its...
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Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept: Determination of the optimal dynamic infrared heater temperature during primary drying
Contributor(s):: De Meyer, Laurens, Lammens, Joris, Vanbillemont, Brecht, Van Bockstal, Pieter Jan, Corver, Jos, Vervaet, Chris, Friess, Wolfgang, De Beer, Thomas
The applicability of DCCs in a continuous freeze-drying concept based on spin freezing and infrared heating was evaluated. Maximum applicable filling volume was evaluated. Secondly the mechanistic model for the determination of the optimal dynamic infrared heater temperature during primary drying...