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1. Powder composition monitoring in continuous pharmaceutical solid-dosage form manufacturing using state estimation-Proof of concept

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   09 Jun 2023 | Contributor(s):: Destro, Francesco, Munoz, Salvador Garcia, Bezzo, Fabrizio, Barolo, Massimiliano

   In continuous solid-dosage form manufacturing, the powder feeding system is responsible for supplying downstream the correct formulation of the drug product ingredients. The composition of the powder delivered by the feeding system is inferred from the measurements of powder mass flow from the...

2. Evaluation of a Combined MHE-NMPC Approach to Handle Plant-Model Mismatch in a Rotary Tablet Press

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   09 Jun 2023 | Contributor(s):: Huang, Yan-Shu, Reklaitis, Gintaras V.

   The transition from batch to continuous processes in the pharmaceutical industry has been driven by the potential improvement in process controllability, product quality homogeneity, and reduction of material inventory. A quality-by-control (QbC) approach has been implemented in a variety of...