Modeling a seeded continuous crystallizer for the production of active pharmaceutical ingredients
Contributor(s):: Besenhard, M. O., Hohl, R. Hodzic, A. Eder, R. J.P., Khinast, J. G.
The approximation of a well mixed reactor is prevalent when it comes to the modeling of a crystallization process. Since temperature, concentration, and mass content vary due to inhomogeneous mixing, this approximation is a very loose one. The continuously operated seeded tubular crystallizer...
Advanced control of a continuous oscillatory flow crystalliser
Contributor(s):: Tahir, F, Krzemieniewska-Nandwani, KMack, J, Lovett, D, Siddique, H, Mabbott, F, Raval, V, Houson, I, Florence, A
This paper presents the application and challenges of achieving Model Predictive Control (MPC) on two continuous oscillatory baffled crystallisation reactors, delivering precise product quality control in the face of raw material fluctuations. A key advantage of MPC is that it effectively deals...